Know Your Disease
Preparation for Transplant
Transplant process
Patient Stories
Myths & Facts - Donation
Become A Donor
To join the Registry, you need..Read More
About MDR(I)
The MDR(I) is a database of voluntary Donors..Read More
- MDR(I) Registration form
- MDR(I) Donation form
> Transplant Process - Information for patients in need of a stem cell transplant  
Unrelated Donor Search
Since you do not have a suitable donor in your family, your transplant center can search the Marrow Donor Registry(India), MDR(I) for an unrelated donor for you. Please initiate your search early.
It can take a long time to select a Donor and prepare for your transplant. Beginning the Donor Search early may improve your chances of getting a transplant when you need one.
The Search Process
Any transplant doctor can ask for a free preliminary search of the MDR(I) for you. When your doctor submits such a request, he will include your HLA tissue typing data which is necessary to match you to your potential donors.
The MDR(I) sends the preliminary search results to your doctor. These early results may show a few potential matches or no matches. Further testing is needed to find out which, if any, of the potential donors are suitable for you.
Since the further search requires higher resolution HLA typing of the potential donors, the donors need to be recalled for fresh blood samples. These tests are expensive and the patient will have to bear the cost for the same.
Both the transplant physician as well as MDR(I) will again explain the donation procedure to the donor who is finally selected.
The transplant physician will arrange for the collection of stem cells from the donor and their proper transportation to the transplant center
Human Leukocyte Antigens (HLA)
HLA typing is used to match patients and donors for Stem cell transplant. Currently, the HLA laboratories of the MDR(I) are doing medium resolution HLA typing of the enrolled voluntary donors. Thus, results of HLA-A, HLA-B and HLA-DRB testing are being stored in the database of the MDR(I) by Syntel.
A close match between the patient's and the donor's HLA type can reduce the risk of a transplant failure. A transplant failure maybe due to:
1. Your immune system attacking the donor's stem cells(graft rejection) OR
2. The donor's immune system attacking the recepient's marrow and other tissues( graft versus host disease-GVHD) after successful engraftment.
Importance of Race and Ethnicity in tissue match
Since tissue typing, like other features such as color of hair and eyes, is inherited, the best chance of finding a match is from someone of the same race and ethnicity. In India, with its diverse and varied ethnic population mix, there is a special need to recruit donors that most closely match the tissue type of the patient. Hence, it is important to make a database of donors as large as possible and include citizens from all geographical regions of the country.